the role of interleukin (il-22) in immune response to human diseases
نویسندگان
چکیده
background and aims:il-22 is an α-helical cytokine.il-22 binds to a heterodimeric cell surface receptor composed of il-10r2 and il-22r1subunits.il-22r is expressed on tissue cells and it is absent on immune cells.il-22 and il-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. the aim of this study was to investigate the role of interleukin(il22)in immune response in human diseases.methods:this study was a mini-review research to investigate the role of thelper22(th22)in immune response.result:il-22 can contribute to immune disease through the stimulation of inflammatory responses, s100s and defensins.il-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to il-10.in some contexts, the pro-inflammatory versus tissue-protective functions of il-22 are regulated by the often co-expressed cytokine il-17a.il-22 can innate regulation of antimicrobial proteins. targeting the il-22–il-22r pathway may yield new therapeutic potential for the treatment of certain human diseases conclusion:il-22 is expressed constitutively by lti-like cells within the small intestine, a tissue that is under the careful immune balance between inflammation and tolerance. gaining a better understanding of the expression and role of il-22 in health and disease is important for development of il-22 as a potential drug target il-22 is expressed constitutively by lti-like cells within the small intestine,a tissue that is under the careful immune balance between inflammation and tolerance.gaining a better understanding of the expression and role of il-22 in health and disease is important for development of il-22 as a potential drug target.
منابع مشابه
The Role of Interleukin (IL-22) in immune response to human diseases
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...
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عنوان ژورنال:
international journal of epidemiologic researchناشر: shahrekord university of medical sciences
ISSN
دوره 2
شماره 3 2015
کلمات کلیدی
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